Hello, and thanks XXX XXXXXXX in.
The information I have from a veterinary radiation oncologist states that grade III undifferentiated mast cell tumors have about a 75% chance of metastasizing. Therefore, if this was a situation where you wanted to do everything possible to try and deal with the cancer, another surgery with wider margins would be performed. Chemotherapy could also be done with prednisone and vinblastine, or prednisone and vinblastine and lomustine. But, I completely understand your point that with everything she's gone through, why put her through this, and that is definitely a valid point. Ways to check for metastases include mainly X-rays. Bloodwork is not very good to look for cancer in general in dogs.
I hope this helps.
Dr. Dave
Veterinarian
6 years general small animal practice, 10 years emergency/critical care small animal practice

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