The disease or term PLE means there is protein lose in excess through the intestinal tract and as a result there is a low serum protein causing other problems. Now, PLE usually has an underlying cause. In other words, something else is going on in the body that is causing these protein to be lost. PLE can be caused by cardiovascular disease, parasites, food sensitivity, cancer, inflammatory bowel disease, lymphagiectasis, fungal infections, etc. The list is very long. In addition, the veterinarian also has to exclude other causes that would cause a low serum protein like liver disease, kidney disease, etc. Once the veterinarian determines the underlying cause than treatment is tailored toward that problem.
As far as being a genetic disease, it has not been proved but yorkies is one of the breeds where PLE is seen commonly.
As far as diet, in general we are learning that keeping dogs on a grain free and casein free diet may be best. Food sensitivities is one of the things that can cause PLE. I would recommend get him off gluten (protein found in wheat, barley and rye), corn, soy and casein (dairy). You may want to feed him a home cooked protein source with some potatoes and veggies (broccoli, carrots, etc.).
I would recommend you speak to your veterinarian about trying to find the root of the problem. If your vet does not feel comfortable working this case, than request a referral to an internal medicine specialist.
If you have additional questions I will be glad to answer them.
Dr. Peter

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